Anticancer agent 221

• Description:

  Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 (IC50=22.09 µg/mL) and MCF-7 (IC50=6.40 µg/mL), and induces apoptosis. Anticancer agent 221 exhibits antioxidant efficacy with an IC50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-221.html

• Smiles:

  O=C (NC1=CC2=C (C=C1) C (C=C (C (F) (F) F) O2) =O) C3=CC=C (F) C=C3

• Molecular Formula:

  C17H9F4NO3

• Molecular Weight:

  351.25

• References & Citations:

  [1]Jorepalli S, et al., Synthesis, molecular docking studies and biological evaluation of N- (4-oxo-2- (trifluoromethyl) -4H-chromen-7-yl) benzamides as potential antioxidant, and anticancer agents. Sci Rep. 2024 Apr 29;14 (1) :9866.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4