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Anticancer agent 221

CAT: 0804-HY-163616Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-163616Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 (IC50=22.09 µg/mL) and MCF-7 (IC50=6.40 µg/mL), and induces apoptosis. Anticancer agent 221 exhibits antioxidant efficacy with an IC50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-221.html
Smiles
O=C(NC1=CC2=C(C=C1)C(C=C(C(F)(F)F)O2)=O)C3=CC=C(F)C=C3
Molecular Formula
C17H9F4NO3
Molecular Weight
351.25
References & Citations
[1]Jorepalli S, et al., Synthesis, molecular docking studies and biological evaluation of N- (4-oxo-2- (trifluoromethyl) -4H-chromen-7-yl) benzamides as potential antioxidant, and anticancer agents. Sci Rep. 2024 Apr 29;14 (1) :9866.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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