UB-221

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  UB-221 is a humanized IgG1 monoclonal antibody inhibitor that targets IgE. It significantly reduces IgE synthesis by stabilizing the membrane-bound CD23 on B lymphocytes and inhibits Fc?RI-mediated activation and degranulation of basophils. UB-221 lowers IgE levels in cynomolgus monkeys and human IgE (?, ?) transgenic (hIGHE knock-in) mice, making it relevant for asthma and chronic spontaneous urticaria (CSU) research.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2755114-30-6