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UB-221

CAT: 0931-T9901A-1750-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1750-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2755114-30-6
Target
Others
Related Pathways
Others
Bioactivity
UB-221 is a humanized IgG1 monoclonal antibody inhibitor that targets IgE. It significantly reduces IgE synthesis by stabilizing the membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated activation and degranulation of basophils. UB-221 lowers IgE levels in cynomolgus monkeys and human IgE (ε, κ) transgenic (hIGHE knock-in) mice, making it relevant for asthma and chronic spontaneous urticaria (CSU) research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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