HO 221

• Description :

  HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia[1].

• CAS Number :

  [105128-93-6]

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  ClC1=C(OC2=NC=C(Br)C=N2)C=CC(NC(NC(C3=C(C=CC=C3)[N+]([O-])=O)=O)=O)=C1

• Molecular Formula :

  C18H11BrClN5O5

• Molecular Weight :

  492.67

• References & Citations :

  [1]Nakajima T, et al. Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221. Cancer Chemother Pharmacol. 1991;28 (5) :351-6.|[2]Nakajima T, et al. Mechanism of tumor cell killing by HO-221, a novel antitumor compound. Cancer Chemother Pharmacol. 1990;27 (3) :199-204.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1