TNIK-IN-5

TNIK-IN-5

• CAS Number: 2754265-66-0
• UNSPSC Description: TNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1].
• Target Antigen: Wnt
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tnik-in-5.html
• Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1OC2=CC(C3=CN=C(NC=C4)C4=C3)=CC=C2N1CC5=CC=CC(OC)=C5
• Molecular Weight: 371.39
• References & Citations: [1]Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported