Laxiflorin B-4

Laxiflorin B-4

• CAS Number: 2810956-32-0
• UNSPSC Description: Laxiflorin B-4 is modificative compound of Laxiflorin B (HY-156393), exhibited higher affinity for ERK1/2 and stronger tumor suppression[1].
• Target Antigen: ERK
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/laxiflorin-b-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1[C@@](C2[C@@]3(C[C@@H](CC2)C4=C)C4=O)([C@@H](C(C)(C=C1)C)COC(C5=CN(N=C5)C6=CC=CN=C6)=O)COC3=O
• Molecular Weight: 515.56
• References & Citations: [1]Cheng-Yao Chiang, et al. A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer. Acta Pharmacol Sin. 2023 Oct 10.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported