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MAO-A/B-IN-4

CAT: 0804-HY-175723Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175723Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections[1].
UNSPSC
12352005
Target
Bacterial; Monoamine Oxidase
Related Pathways
Anti-infection; Neuronal Signaling
Field of Research
Infection
Smiles
O=C1O[C@H](CN1C2=CC(F)=C(C(F)=C2)C3=CN=C(C=C3)/C=N/N4CCOCC4)CN5C=CN=N5
Molecular Formula
C22H21F2N7O3
Molecular Weight
469.44
References & Citations
[1]Duan M, et al. Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcus aureus. J Med Chem. 2025 Aug 28;68 (16) :16958-16988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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