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TLR7 agonist 16

CAT: 0804-HY-156177Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156177Size:1 Each
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Description
TLR7 agonist 16 (compound 16d) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 16 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations[1].
CAS Number
2832199-56-9
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-16.html
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)C)NC1=CC=C(CN2C(CCCC)=NC3=C2C4=CC=CC=C4N=C3N)C=C1
Molecular Formula
C25H29N5O2
Molecular Weight
431.53
References & Citations
[1]Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14 (10) :1358-1368.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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