VS-5584

• Description :

  VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks mTORC2 as well as mTORC1.

• Product Name Alternative :

  SB2343

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  MTOR; PI3K

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/vs-5584.html

• Purity :

  98.71

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  NC1=NC=C(C2=C3N=C(C)N(C(C)C)C3=NC(N4CCOCC4)=N2)C=N1

• Molecular Formula :

  C17H22N8O

• Molecular Weight :

  354.41

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Hart S, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther, 2013, 12 (2), 151-161.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  MTOR; mTORC1; mTORC2; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34

• CAS Number :

  [1246560-33-7]