VS-5584

CAT: 0804-HY-16585-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16585-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks mTORC2 as well as mTORC1.
CAS Number
[1246560-33-7]
Product Name Alternative
SB2343
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vs-5584.html
Purity
98.71
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=C3N=C(C)N(C(C)C)C3=NC(N4CCOCC4)=N2)C=N1
Molecular Formula
C17H22N8O
Molecular Weight
354.41
Precautions
H315, H319, H335
References & Citations
[1]Hart S, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther, 2013, 12 (2), 151-161.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTOR; mTORC1; mTORC2; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34

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T6103-01VS-5584
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A3927-5.1VS-5584 (SB2343)
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A12480-5VS-5584 5mg
A12480-50VS-5584 50mg
A12480-10VS-5584 10mg
A12480-100VS-5584 100mg
A12480-200VS-5584 200mg

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