VS 8

• UNSPSC Description:

  VS 8 (Compound VS 8) is a potent, orally active VEGFR-2 inhibitor with significant anti-angiogenic effects. VS 8 induces cancer cell apoptosis and migration. VS 8 is active against CSCs (Cancer stem cells)[1].

• Target Antigen:

  Apoptosis; Reactive Oxygen Species; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vs-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC1=CC=C(OC2=C3C=CC=C(NC(NC4=CC=CC(C(F)(F)F)=C4)=O)C3=CC=C2)C=C1)=O

• Molecular Weight:

  479.45

• References & Citations:

  [1]Siddharth J Modi, et al. Discovery of VEGFR-2 inhibitors exerting significant anticancer activity against CD44+ and CD133+ cancer stem cells (CSCs): Reversal of TGF-β induced epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma. Eur J Med Chem. 2020 Dec 1;207:112851.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2471865-38-8