22- (4′-py) -JA

• Description :

  22- (4′-py) -JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.) . 22- (4′-py) -JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22- (4′-py) -JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) . 22- (4′-py) -JA has potent anticancer activity against non-small cell lung cancer (NSCLC) [1].

• Product Name Alternative :

  22- (4′-Pyridinecarbonyl) jorunnamycin A

• UNSPSC :

  12352005

• Target :

  Akt; mTOR

• Type :

  Natural Products

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/22-4-py-ja.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C

• Molecular Formula :

  C32H30N4O8

• Molecular Weight :

  598.60

• References & Citations :

  [1]Iksen I, et al. Preclinical Characterization of 22- (4'-Pyridinecarbonyl) Jorunnamycin A against Lung Cancer Cell Invasion and Angiogenesis via AKT/mTOR Signaling. ACS Pharmacol Transl Sci. 2023 Jul 25;6 (8) :1143-1154.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [1178895-15-2]