22- (4′-py) -JA

CAT: 0804-HY-155721Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155721Size:1 Each
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Description
22- (4′-py) -JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.) . 22- (4′-py) -JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22- (4′-py) -JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) . 22- (4′-py) -JA has potent anticancer activity against non-small cell lung cancer (NSCLC) [1].
CAS Number
[1178895-15-2]
Product Name Alternative
22- (4′-Pyridinecarbonyl) jorunnamycin A
UNSPSC
12352005
Target
Akt; mTOR
Type
Natural Products
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/22-4-py-ja.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C
Molecular Formula
C32H30N4O8
Molecular Weight
598.60
References & Citations
[1]Iksen I, et al. Preclinical Characterization of 22- (4'-Pyridinecarbonyl) Jorunnamycin A against Lung Cancer Cell Invasion and Angiogenesis via AKT/mTOR Signaling. ACS Pharmacol Transl Sci. 2023 Jul 25;6 (8) :1143-1154.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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