22-(4′-py)-JA

22-(4′-py)-JA

• CAS Number: 1178895-15-2
• UNSPSC Description: 22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1].
• Target Antigen: Akt; mTOR
• Type: Natural Products
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/22-4-py-ja.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C
• Molecular Weight: 598.60
• References & Citations: [1]Iksen I, et al. Preclinical Characterization of 22-(4'-Pyridinecarbonyl) Jorunnamycin A against Lung Cancer Cell Invasion and Angiogenesis via AKT/mTOR Signaling. ACS Pharmacol Transl Sci. 2023 Jul 25;6(8):1143-1154.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported