PY-60

• Description:

  PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 µM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1].

• UNSPSC:

  12352005

• Target:

  Annexin A; YAP

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/py-60.html

• Purity:

  99.42

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=NOC (C2=CC=CC=C2) =C1) NCCCC3=NC=CS3

• Molecular Formula:

  C16H15N3O2S

• Molecular Weight:

  313.37

• References & Citations:

  [1]Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17 (7) :767-775.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2765218-56-0