PY-PAP

CAT: 0804-HY-176548Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176548Size:1 Each
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Description
PY-PAP is a photoactivatable affinity probe and a derivative of PY-60 (HY-141644) . PY-PAP retains the cellular function of activating YAP transcriptional activity. In 293A cells, PY-PAP can label cathepsin D (CTSD) and annexin A2 (ANXA2) through ultraviolet crosslinking and click reactions. PY-PAP plays a key role in identifying ANXA2 as the specific target of PY-60[1].
CAS Number
[2765218-57-1]
UNSPSC
12352005
Target
Annexin A; YAP
Related Pathways
Cytoskeleton; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCN3CCN(CC3)C(CCC4(CCC#C)N=N4)=O
Molecular Formula
C25H30N6O3
Molecular Weight
462.54
References & Citations
[1]Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021 Jul;17 (7) :767-775.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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