PY-PAP

• Description :

  PY-PAP is a photoactivatable affinity probe and a derivative of PY-60 (HY-141644) . PY-PAP retains the cellular function of activating YAP transcriptional activity. In 293A cells, PY-PAP can label cathepsin D (CTSD) and annexin A2 (ANXA2) through ultraviolet crosslinking and click reactions. PY-PAP plays a key role in identifying ANXA2 as the specific target of PY-60[1].

• UNSPSC :

  12352005

• Target :

  Annexin A; YAP

• Related Pathways :

  Cytoskeleton; Stem Cell/Wnt

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCN3CCN(CC3)C(CCC4(CCC#C)N=N4)=O

• Molecular Formula :

  C25H30N6O3

• Molecular Weight :

  462.54

• References & Citations :

  [1]Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021 Jul;17 (7) :767-775.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2765218-57-1]