22- (4?-py) -JA

• Target:

  Akt|||mTOR

• Related Pathways:

  Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling

• Bioactivity:

  22- (4?-py) -JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1? (HIF-1?), and vascular endothelial growth factor (VEGF) . Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].

• Smiles:

  C (OC (=O) C=1C=CN=CC1) [C@@H]2N3[C@] ([C@]4 (C5=C (C[C@@] ([C@@H]3C#N) (N4C) [H]) C (=O) C (C) =C (OC) C5=O) [H]) (CC6=C2C (=O) C (OC) =C (C) C6=O) [H]

• Molecular Formula:

  C32H30N4O8

• Molecular Weight:

  598.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1178895-15-2