Beauverolide Ja

• UNSPSC Description:

  Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea[1].

• Target Antigen:

  Calmodulin; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/beauverolide-ja.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@H](C(N[C@](C(OC(CC(N1)=O)C(C)CCCC)=O)([H])[C@@H](C)CC)=O)CC2=CC=CC=C2)[C@@H]1CC3=CNC4=CC=CC=C34

• Molecular Weight:

  602.76

• References & Citations:

  [1]Abraham Madariaga-Mazón, et al. Potent anti-calmodulin activity of cyclotetradepsipeptides isolated from Isaria fumosorosea using a newly designed biosensor. Nat Prod Commun. 2015 Jan;10(1):113-6.|[2]Qunfang Weng, et al. Secondary Metabolites and the Risks of Isaria fumosorosea and Isaria farinose. Molecules. 2019 Feb 13;24(4):664.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  76265-41-3