SARS-CoV-2 3CLpro-IN-14

SARS-CoV-2 3CLpro-IN-14

• CAS Number: 2945139-50-2
• UNSPSC Description: SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti-SARS-CoV-2 activity (EC50 = 0.18 μM) and low cytotoxicity (CC50 > 50 μM) in Vero E6 cells[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-3clpro-in-14.html
• Solubility: 10 mM in DMSO
• Smiles: FC(F)(F)S(=O)(N[C@H](C(N1[C@@H](C2)CC[C@@H]2[C@H]1C(N[C@H](C(C3=NC4=CC=CC=C4S3)=O)C[C@@H]5CCNC5=O)=O)=O)C6(C7)C[C@@H](C8)C[C@H]7C[C@@H]8C6)=O
• Molecular Weight: 735.84
• References & Citations: [1]Yang H, et al. Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2. Eur J Med Chem. 2023 Sep 5;257:115512.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported