SARS-CoV-2 3CLpro-IN-14

• UNSPSC Description:

  SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti-SARS-CoV-2 activity (EC50 = 0.18 μM) and low cytotoxicity (CC50 > 50 μM) in Vero E6 cells[1].

• Target Antigen:

  SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sars-cov-2-3clpro-in-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(F)S(=O)(N[C@H](C(N1[C@@H](C2)CC[C@@H]2[C@H]1C(N[C@H](C(C3=NC4=CC=CC=C4S3)=O)C[C@@H]5CCNC5=O)=O)=O)C6(C7)C[C@@H](C8)C[C@H]7C[C@@H]8C6)=O

• Molecular Weight:

  735.84

• References & Citations:

  [1]Yang H, et al. Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2. Eur J Med Chem. 2023 Sep 5;257:115512.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2945139-50-2