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SARS-CoV-2 3CLpro-IN-5

CAT: 0804-HY-151535Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151535Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CLpro) . SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CLpro with an IC50 value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA) . SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19) [1].
CAS Number
2913186-57-7
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-3clpro-in-5.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=CC2=C1C=C(C(N[C@H](C(NN(C([C@@](F)([H])Cl)=O)C[C@H]3C(NCC3)=O)=O)CC(C)C)=O)N2
Molecular Formula
C22H26ClF2N5O4
Molecular Weight
497.92
References & Citations
[1]Yuya Hirose, et al. Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease. J Med Chem
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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