SARS-CoV-2 3CLpro-IN-27

• UNSPSC Description:

  SARS-CoV-2 3CLpro-IN-27 (Compound 9H) is an inhibitor of SARS-CoV-2 3CLpro with an IC50 value of 21 nM. SARS-CoV-2 3CLpro-IN-27 exhibits excellent anti-SARS-CoV-2 replicon activity, demonstrating an EC50 value of 5 nM[1].

• Target Antigen:

  SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sars-cov-2-3clpro-in-27.html

• Smiles:

  FC1=CC=C(C[C@H](N(C([C@H](C2CC2)NC(C(F)(F)F)=O)=O)C)C(N3[C@H](C#N)C[C@]4(C(NC5=C4C=CC=C5)=O)C3)=O)C=C1

• Molecular Weight:

  585.55

• References & Citations:

  [1]Guma S D, et al. Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2[J]. European Journal of Medicinal Chemistry, 2024: 117004.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported