SARS-CoV-2 3CLpro-IN-27

SARS-CoV-2 3CLpro-IN-27

• UNSPSC Description: SARS-CoV-2 3CLpro-IN-27 (Compound 9H) is an inhibitor of SARS-CoV-2 3CLpro with an IC50 value of 21 nM. SARS-CoV-2 3CLpro-IN-27 exhibits excellent anti-SARS-CoV-2 replicon activity, demonstrating an EC50 value of 5 nM[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-3clpro-in-27.html
• Smiles: FC1=CC=C(C[C@H](N(C([C@H](C2CC2)NC(C(F)(F)F)=O)=O)C)C(N3[C@H](C#N)C[C@]4(C(NC5=C4C=CC=C5)=O)C3)=O)C=C1
• Molecular Weight: 585.55
• References & Citations: [1]Guma S D, et al. Discovery of peptidomimetic spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2[J]. European Journal of Medicinal Chemistry, 2024: 117004.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported