PSB-22034

• UNSPSC Description:

  PSB-22034 (compound 30d) is a selective agonist of MRGPRX4 with EC50s of 11.2 nM and 30.0 nM in Ca2+ and β-arrestin experiments, respectively[1].

• Target Antigen:

  Mas-related G-protein-coupled Receptor (MRGPR)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mrgprx4-agonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(N(C(N1CC#C)=O)CCCCP(O)(O)=O)N=C(N2)CCC3=CC(OC)=CC=C3

• Molecular Weight:

  460.42

• References & Citations:

  [1]Marx D et al. Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4). J Med Chem. 2023 Nov 15.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2768131-22-0