PSB-22034

• Description :

  PSB-22034 (compound 30d) is a selective agonist of MRGPRX4 with EC50s of 11.2 nM and 30.0 nM in Ca2+ and β-arrestin experiments, respectively[1].

• UNSPSC :

  12352005

• Target :

  Mas-related G-protein-coupled Receptor (MRGPR)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mrgprx4-agonist-1.html

• Purity :

  99.0000

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=C(N(C(N1CC#C)=O)CCCCP(O)(O)=O)N=C(N2)CCC3=CC(OC)=CC=C3

• Molecular Formula :

  C21H25N4O6P

• Molecular Weight :

  460.42

• References & Citations :

  [1]Marx D et al. Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4) . J Med Chem. 2023 Nov 15.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2768131-22-0]