Boc-MIF-1-Am

Boc-MIF-1-Am

• UNSPSC Description: Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC50=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells[1].
• Target Antigen: Dopamine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/boc-mif-1-am.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CC(C)C)C(NCC(NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)=O)=O)[C@H]4N(C(OC(C)(C)C)=O)CCC4
• Molecular Weight: 518.69
• References & Citations: [1]Silva-Reis S C et al. Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors[J]. ACS Medicinal Chemistry Letters, 2023.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported