MIF-1

CAT: 0804-HY-107663Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107663Size:1 Each
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Description
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) [1][2][3].
CAS Number
[2002-44-0]
Product Name Alternative
Pro-Leu-Gly-NH2; Melanostatin
UNSPSC
12352209
Hazard Statement
H315-H319-H320
Target
Dopamine Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mif-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(N)=O)[C@H](CC(C)C)NC([C@@H]1CCCN1)=O
Molecular Formula
C13H24N4O3
Molecular Weight
284.35
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Bocheva A, et, al. Antiopioid properties of the TYR-MIF-1 family. Methods Find Exp Clin Pharmacol. 2004 Nov;26 (9) :673-7.|[2]Valentijn JA, et, al. Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. J Physiol. 1994 Mar 1;475 (2) :185-95.|[3]Saleh MI, et, al. MIF-1 attenuates spiroperidol alteration of striatal dopamine D2 receptor ontogeny. Peptides. 1989 Jan-Feb;10 (1) :35-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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