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ALR-27

CAT: 0804-HY-155408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155408Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].
CAS Number
903639-13-4
UNSPSC
12352005
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alr-27.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C=C1)CCC2CCC(CO2)C3=CC=C(C=C3)O
Molecular Formula
C19H22O3
Molecular Weight
298.38
References & Citations
[1]Cerchia C et al. Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. Eur J Med Chem. 2023 Nov 8;263:115932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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