ALR-27

• Target :

  FLAP

• Related Pathways :

  Immunology/Inflammation

• Bioactivity :

  ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].

• Smiles :

  C(CC1=CC=C(O)C=C1)C2CCC(CO2)C3=CC=C(O)C=C3

• Molecular Formula :

  C19H22O3

• Molecular Weight :

  298.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  903639-13-4