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PRMT1-IN-3

CAT: 0804-HY-175821Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175821Size:1 Each
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Description
PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 4.11 μM. PRMT1-IN-3 inhibits PRMT6 and PRMT8 with IC50s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel. PRMT1-IN-3 can be used for the study of TNBC[1].
CAS Number
892570-48-8
UNSPSC
12352101
Target
Apoptosis; Histone Methyltransferase
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
FC1=CC=C(COC2=C(C=CC=C2)CNCCCNC)C=C1
Molecular Formula
C18H23FN2O
Molecular Weight
302.39
References & Citations
[1]Su Y, et al. Discovery of protein arginine methyltransferase 1 inhibitor by structure-based pharmacophore modeling, virtual screening, molecular dynamics simulations, and the enhancement of paclitaxel's antitumor activity. Eur J Med Chem. 2025 Dec 5;299:118066.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8

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