IACS-52825

• Description:

  IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy[1].

• UNSPSC:

  12352005

• Target:

  MAP3K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/iacs-52825.html

• Purity:

  99.78

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC=C (C=C1OC (F) (F) F) C2=CN (C ([C@@H] (O) C (F) (F) F) =N2) C34CC (C3) (C4) F

• Molecular Formula:

  C16H13F7N4O2

• Molecular Weight:

  426.29

• References & Citations:

  [1]Kang Le, et al. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 27;66 (14) :9954-9971.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2640376-72-1