IACS-52825

CAT: 0804-HY-155089-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155089-01Size:1 mg
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Description
IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy[1].
CAS Number
[2640376-72-1]
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iacs-52825.html
Purity
99.78
Solubility
10 mM in DMSO
Smiles
NC1=NC=C(C=C1OC(F)(F)F)C2=CN(C([C@@H](O)C(F)(F)F)=N2)C34CC(C3)(C4)F
Molecular Formula
C16H13F7N4O2
Molecular Weight
426.29
References & Citations
[1]Kang Le, et al. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 27;66 (14) :9954-9971.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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