IACS-52825

• Description :

  IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy[1].

• UNSPSC :

  12352005

• Target :

  MAP3K

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/iacs-52825.html

• Purity :

  99.78

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=NC=C(C=C1OC(F)(F)F)C2=CN(C([C@@H](O)C(F)(F)F)=N2)C34CC(C3)(C4)F

• Molecular Formula :

  C16H13F7N4O2

• Molecular Weight :

  426.29

• References & Citations :

  [1]Kang Le, et al. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 27;66 (14) :9954-9971.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2640376-72-1]