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FGFR4-IN-17

CAT: 0804-HY-163273Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163273Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FGFR4-IN-17 (Compound (S) -23) is a piperazinyl diflurindan derivative containing pyridinyl. FGFR4-IN-17 is a FGFR inhibitor with IC50 values of 24.2, 16.1, 78.0, and 68.0 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. FGFR4-IN-17 has antitumor activity[1].
CAS Number
3011805-61-8
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr4-in-17.html
Solubility
10 mM in DMSO
Smiles
FC1(C2=CC(NC(C3=CC(C#CC4=CN=CC(OC)=C4)=C(C=C3)F)=O)=CC=C2[C@@H](N5CCN(CC5)C)C1)F
Molecular Formula
C29H27F3N4O2
Molecular Weight
520.55
References & Citations
[1]Ding W, et al. Identification of Piperazinyl-Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation. J Med Chem. 2024 Jan 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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