Rev 2’-O-MOE-C(Bz)-5’-amidite

Rev 2’-O-MOE-C(Bz)-5’-amidite

• UNSPSC Description: Rev 2’-O-MOE-C(Bz)-5’-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/rev-2-o-moe-c-bz-5-amidite.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N=C(NC(C2=CC=CC=C2)=O)C=CN1[C@@H]3O[C@@H]([C@H]([C@H]3OCCOC)OC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)COP(N(C(C)C)C(C)C)OCCC#N
• Molecular Weight: 907.99
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported