Rev 2’-O-MOE-A(Bz)-5’-amidite

• UNSPSC Description:

  Rev 2’-O-MOE-A(Bz)-5’-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rev-2-o-moe-a-bz-5-amidite.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)N(C(C)C)P(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(NC(C4=CC=CC=C4)=O)=NC=N3)[C@H](OCCOC)[C@@H]1OC(C5=CC=CC=C5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)OCCC#N

• Molecular Weight:

  932.01

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported