3’-O-MOE-A(Bz)-2’-CED-phosphoramidite

• UNSPSC Description:

  3’-O-MOE-A(Bz)-2’-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3-o-moe-a-bz-2-ced-phosphoramidite.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=CC=C1)NC2=NC=NC3=C2N=CN3[C@H]4[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@H](OCCOC)[C@@H](COC(C5=CC=CC=C5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)O4

• Molecular Weight:

  932.01

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  256224-01-8