CBP-IN-1

CAT:

804-HY-153948

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CAS Number: 1936431-44-5
UNSPSC Description: CBP-IN-1 (compound 12) is a potent CBP inhibitor, with an IC50 of 1.5 nM. CBP-IN-1 also inhibits CBP BRET and BRD4(1), with IC50 values of 690 and 3100 nM, respectively[1].
Target Antigen: Epigenetic Reader Domain
Type: Reference compound
Related Pathways: Epigenetics
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/cbp-in-1.html
Solubility: 10 mM in DMSO
Smiles: O=C(C)N1CC2=C(CC1)N(C3CCNCC3)N=C2N4C5=C(CCC4)C=C(C6=CN(C)N=C6)C(C(F)F)=C5
Molecular Weight: 509.59
References & Citations: [1]Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183. |[2]Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-153948	CBP-IN-1
HY-111420-03	CBP/p300-IN-1
HY-160260	EP300/CBP-IN-1
HY-111420-06	CBP/p300-IN-1
HY-111420-05	CBP/p300-IN-1
HY-111420-04	CBP/p300-IN-1
HY-111420-02	CBP/p300-IN-1
HY-111420-01	CBP/p300-IN-1
HY-164005	CBP/EP300 bromodomain receptor-IN-1
HY-143441	CBP/p300-IN-17