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CBP-1018

CAT: 0804-HY-P10740Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10740Size:1 Each
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Description
CBP-1018 is a PDC (peptide drug conjugate) consisting of a dual targeting FRĪ±/prostate-specific membrane antigen (PSMA) ligand (blue part) coupled to Monomethyl auristatin E (HY-15162) (red part) via a linker (HY-78738) (black part) . CBP-1018 is expected to be used in breast cancer research[1].
CAS Number
[2923068-30-6]
UNSPSC
12352209
Target
Antifolate; Peptide-Drug Conjugates (PDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-1018.html
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C(CC4=O)SC[C@@H](C(N[C@H](C(N)=O)CCCCNC(CC[C@@H](C(O)=O)NC(C5=CC=C(C=C5)NCC(N=C67)=CNC6=NC(N)=NC7=O)=O)=O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CC(O)=O)NC(CC8=CC=C(C=C8)CNC(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C132H192N30O38S
Molecular Weight
2839.18
References & Citations
[1]Li X, et al. LC-MS/MS method for dual-ligand peptide-drug CBP-1018 and its deconjugated payload MMAE including sample stabilization strategy for its MC-Val-Cit-PABC linker. Talanta. 2024 Nov 1;279:126596.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 1

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