COX-2-IN-27

CAT: 0804-HY-150551Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-150551Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 μM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1].

CAS Number

2413565-17-8

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-in-27.html

Solubility

10 mM in DMSO

Smiles

CSC1=NC2=CC=CC=C2N1C3=CSC(NC/C(C)=N/N=C4SC=C(C5=CC=C(Cl)C=C5)N\4C6=CC=CC=C6)=N3

Molecular Formula

C29H24ClN7S3

Molecular Weight

602.20

References & Citations

[1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28 (7) :115403.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-1; COX-2

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T209034-01	COX-2-IN-37
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COX-2-IN-27

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