SHP2-IN-14

SHP2-IN-14

• CAS Number: 2673400-91-2
• UNSPSC Description: SHP2-IN-14 (Compound 27) is a SHP2 allosteric inhibitor (IC50: 7 nM). SHP2-IN-14 has high blood concentration and area under the curve, and has good pharmacokinetic property[1].
• Target Antigen: SHP2
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/shp2-in-14.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C2C(C3=C(Cl)C(Cl)=NC=C3)=NNC2=NC(N4CCC(C5=CC=CC=C5)(N)CC4)=N1)N
• Molecular Weight: 483.35
• References & Citations: [1]Huang X, et al. Preparation of heteroaryl derivatives as antitumor agents. World Intellectual Property Organization, WO2021143680 A1 2021-07-22.|[2]Huang, Xiangui. Heteroaryl derivative and preparation method and application thereof. Patent. CN114867720.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported