LRRK2-IN-1

LRRK2-IN-1

• CAS Number: 1234480-84-2
• UNSPSC Description: LRRK2-IN-1 is a potent and selective?LRRK2?inhibitor with?IC50?of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.
• Target Antigen: Apoptosis; LRRK2
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy
• Applications: Cancer-Kinase/protease
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/LRRK2-IN-1.html
• Purity: 99.42
• Solubility: DMSO : 30 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC(OC)=C(NC2=NC=C3C(N(C4=C(C(N3C)=O)C=CC=C4)C)=N2)C=C1)N5CCC(CC5)N6CCN(CC6)C
• Molecular Weight: 570.69
• References & Citations: [1]Hermanson SB, et al. Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation.PLoS One. 2012;7(8):e43580. Epub 2012 Aug 28.|[2]Deng, Xianming., et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology (2011), 7(4), 203-205.|[3]Koshibu K, et al. Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease. Pharmacology. 2015;96(5-6):240-7.|[4]Weygant N, et al. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 6;13:103.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported