Cabergoline-d6

• Description:

  Cabergoline-d6 is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively) .

• Product Name Alternative:

  FCE-21336-d6

• UNSPSC:

  12352005

• Target:

  Autophagy; Dopamine Receptor; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Autophagy; GPCR/G Protein; Neuronal Signaling; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CCN1[C@@]2([H])[C@@](C[C@H](C1)C(N(CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C(NCC)=O)=O)([H])C3=CC=CC4=C3C(C2)=CN4

• Molecular Formula:

  C26H31D6N5O2

• Molecular Weight:

  457.64

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155 (11) :4411-21.|[3]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9 (6) :e99271.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT2 Receptor; D2 Receptor; D3 Receptor

• CAS Number:

  [2738376-76-4]