Cabergoline-d6

CAT: 0804-HY-15296S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15296S1Size:1 mg
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Description
Cabergoline-d6 is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively) .
CAS Number
[2738376-76-4]
Product Name Alternative
FCE-21336-d6
UNSPSC
12352005
Target
Autophagy; Dopamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
C=CCN1[C@@]2([H])[C@@](C[C@H](C1)C(N(CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C(NCC)=O)=O)([H])C3=CC=CC4=C3C(C2)=CN4
Molecular Formula
C26H31D6N5O2
Molecular Weight
457.64
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155 (11) :4411-21.|[3]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9 (6) :e99271.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; D2 Receptor; D3 Receptor

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