Cabergoline-d5

• Description :

  Cabergoline-d5 is the deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively) [1][2].

• Product Name Alternative :

  FCE-21336-d5

• UNSPSC :

  12352005

• Target :

  Autophagy; Dopamine Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Autophagy; GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Endocrinology

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]/C([2H])=C([2H])\C([2H])([2H])N1[C@@]2([H])[C@@](C[C@H](C1)C(N(CCCN(C)C)C(NCC)=O)=O)([H])C3=CC=CC4=C3C(C2)=CN4

• Molecular Formula :

  C26H32D5N5O2

• Molecular Weight :

  456.64

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9 (6) :e99271.|[3]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155 (11) :4411-21.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor; D2 Receptor; D3 Receptor

• CAS Number :

  [1426173-20-7]