Cabergoline

• Description :

  Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively) .

• Product Name Alternative :

  FCE-21336

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  Autophagy; GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Cabergoline.html

• Purity :

  99.86

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  C=CCN1[C@@]2([H])[C@@](C[C@H](C1)C(N(CCCN(C)C)C(NCC)=O)=O)([H])C3=CC=CC4=C3C(C2)=CN4

• Molecular Formula :

  C26H37N5O2

• Molecular Weight :

  451.60

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9 (6) :e99271.|[2]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155 (11) :4411-21.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT2 Receptor; D2 Receptor; D3 Receptor

• CAS Number :

  [81409-90-7]