Cabergoline

• UNSPSC Description:

  Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).

• Target Antigen:

  Autophagy; Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  Autophagy;GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cabergoline.html

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  C=CCN1[C@@]2([H])[C@@](C[C@H](C1)C(N(CCCN(C)C)C(NCC)=O)=O)([H])C3=CC=CC4=C3C(C2)=CN4

• Molecular Weight:

  451.60

• References & Citations:

  [1]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9(6):e99271.|[2]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155(11):4411-21.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  81409-90-7