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CD73-IN-14

CAT: 0804-HY-152074Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-152074Size:1 Each
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Description
D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity[1]. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2407356-67-4
UNSPSC
12352005
Target
CD73
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cd73-in-14.html
Solubility
10 mM in DMSO
Smiles
ClC1=NC2=C(N=CN2[C@H]3[C@@H]([C@@](C#C)([C@H](O3)COC(CC4=CC=C(C=C4)N5C(NCCC5)=O)(C(O)=O)C(O)=O)O)O)C(N)=N1
Molecular Formula
C26H26ClN7O9
Molecular Weight
615.98
References & Citations
[1]Li J, et al. Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity. J Med Chem. 2022 Dec 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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