CD73-IN-14

• UNSPSC Description:

  D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity[1]. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  CD73

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cd73-in-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=NC2=C(N=CN2[C@H]3[C@@H]([C@@](C#C)([C@H](O3)COC(CC4=CC=C(C=C4)N5C(NCCC5)=O)(C(O)=O)C(O)=O)O)O)C(N)=N1

• Molecular Weight:

  615.98

• References & Citations:

  [1]Li J, et al. Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity. J Med Chem. 2022 Dec 18.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2407356-67-4