CD73-IN-4

• Description:

  CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology[1].

• UNSPSC:

  12352005

• Target:

  CD73

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cd73-in-4.html

• Concentration:

  10mM

• Purity:

  99.21

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  ClC1=NC (N ([C@@H] ([C@H] (O) [C@@H]2O) O[C@@H]2COCP (O) (O) =O) N=C3) =C3C (NC4CCCC4) =N1

• Molecular Formula:

  C16H23ClN5O7P

• Molecular Weight:

  463.81

• References & Citations:

  [1]Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2216764-29-1