CD73-IN-20

• Description:

  CD73-IN-20 (Compound 5c) is an e5′NT (CD73) inhibitor (IC50: 0.37 μM) . CD73-IN-20 also inhibits other ectonucleotidases, with IC50s of 1.12 μM (h-ENPP1), 1.37 μM (h-ENPP3), 1.66 μM (r-e5′NT), 1.48 μM (h-TNAP), respectively. CD73-IN-20 can be used for cancer research[1].

• UNSPSC:

  12352005

• Target:

  CD73; Phosphatase; Phosphodiesterase (PDE)

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  O=C(CC1=CNC2=CC=CC=C21)NC3=CC=CC=C3OS(C4=CC=C(C=C4)F)(=O)=O

• Molecular Formula:

  C22H17FN2O4S

• Molecular Weight:

  424.44

• References & Citations:

  [1]Khan Jadoon MS, et al. Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors. RSC Adv. 2023 Oct 10;13 (42) :29496-29511.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported