hCA/Wnt/β-catenin-IN-1

hCA/Wnt/β-catenin-IN-1

• CAS Number: 3032826-63-1
• UNSPSC Description: hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line[1].
• Target Antigen: Carbonic Anhydrase; P-glycoprotein; Wnt; β-catenin
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hca-wnt-β-catenin-in-1.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=S(C1=CC=C(N2C=C(C3=CC=CC=C3)C(C(C4=CC(OC)=C(OC)C(OC)=C4)=O)=C2)C=C1)(N)=O
• Molecular Weight: 492.54
• References & Citations: [1]Masci D, et al. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. J Med Chem. 2023 Oct 30.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported