hCA/Wnt/β-catenin-IN-1

• UNSPSC Description:

  hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line[1].

• Target Antigen:

  Carbonic Anhydrase; P-glycoprotein; Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hca-wnt-β-catenin-in-1.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC=C(N2C=C(C3=CC=CC=C3)C(C(C4=CC(OC)=C(OC)C(OC)=C4)=O)=C2)C=C1)(N)=O

• Molecular Weight:

  492.54

• References & Citations:

  [1]Masci D, et al. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. J Med Chem. 2023 Oct 30.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  3032826-63-1