hCA XII/II/IX-IN-1

hCA XII/II/IX-IN-1

• UNSPSC Description: hCA XII/II/IX-IN-1 (Compound 3) is a potent human carbonic anhydrase (hCA) inhibitor with IC50 values of 2.6, 0.004, 0.005 and 0.001 μM against hCA I, hCA II, hCA IX and hCA XII, respectively. hCA XII/II/IX-IN-1 shows anticancer activity[1].
• Target Antigen: Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hca-xii-ii-ix-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@H]1[C@@]2([H])[C@@]34[C@]([H])([C@H]([C@H](O[C@@H]3O[C@@](C)(CC2)OO4)OCCC5=CN(C6=CC=C(S(=O)(N)=O)C=C6)N=N5)C)CC1
• Molecular Weight: 534.63
• References & Citations: [1]An R, et al. Discovery of novel artemisinin-sulfonamidehybrids as potential carbonicanhydraseIX inhibitors with improved antiproliferative activities. Bioorg Chem. 2020 Nov;104:104347.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported