HCA I-IN-2

• Description :

  HCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with Ki values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively[1].

• UNSPSC :

  12352005

• Target :

  Carbonic Anhydrase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hca-i-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NS(=O)(C1=CC=C(C=C1)N2C=C(N=N2)CN3C=C(C4=CC=CC=C43)/C=C/C(C5=CC=C(C=C5)Br)=O)=O

• Molecular Formula :

  C26H20BrN5O3S

• Molecular Weight :

  562.44

• References & Citations :

  [1]Singh P, et al. Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids. Bioorg Chem. 2020 Jun;99:103839.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CA II; CA I

• CAS Number :

  [2417232-12-1]