CDK8-IN-11 (hydrochloride)

CDK8-IN-11 (hydrochloride)

• UNSPSC Description: CDK8-IN-11 hydrochloride is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM. CDK8-IN-11 hydrochloride inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 hydrochloride can be used in the research of colon cancer[1].
• Target Antigen: CDK; β-catenin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk8-in-11-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(OC3=CC=C(N)N=C3)C=C2.[H]Cl
• Molecular Weight: 424.80
• References & Citations: [1]Yao Yao Yan, et al. Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy. J Med Chem. 2022 Sep 20.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported