CDK8-IN-11 (hydrochloride)

• UNSPSC Description:

  CDK8-IN-11 hydrochloride is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM. CDK8-IN-11 hydrochloride inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 hydrochloride can be used in the research of colon cancer[1].

• Target Antigen:

  CDK; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk8-in-11-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(OC3=CC=C(N)N=C3)C=C2.[H]Cl

• Molecular Weight:

  424.80

• References & Citations:

  [1]Yao Yao Yan, et al. Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy. J Med Chem. 2022 Sep 20.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported