CDK1-IN-5

CDK1-IN-5

• CAS Number: 3032997-20-6
• UNSPSC Description: CDK1-IN-5 (10h) is a selective CDK1 inhibitor with IC50s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer[1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk1-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: S=C(N1CCN(C2=NN=C(CC3=CC=C(OC)C=C3)C4=C2C=CC=C4)CC1)NC5=CC=CC(Cl)=C5
• Molecular Weight: 504.05
• References & Citations: [1]Akl L, et al. Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer. Eur J Med Chem. 2022 Aug 31;243:114704.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported