KDM1/CDK1-IN-1

KDM1/CDK1-IN-1

• CAS Number: 2938990-92-0
• UNSPSC Description: KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively[1].
• Target Antigen: Apoptosis; Caspase; CDK; Histone Demethylase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/kdm1-cdk1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(O)N2C(N=C1)=C(C3=NC4=CC=CC=C4S3)C(NC5=CC=CC=C5)=N2)OCC
• Molecular Weight: 431.47
• References & Citations: [1]Husseiny EM. Synthesis, cytotoxicity of some pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action. Bioorg Chem. 2020 Sep;102:104053.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported