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(Rac) -Lonafarnib

CAT: 0804-HY-15136BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15136BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. Lonafarnib is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities[1].
CAS Number
193275-86-4
Product Name Alternative
Sch66336 (racemate)
UNSPSC
12352005
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/rac-lonafarnib.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CC(N2CCC(C3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N
Molecular Formula
C27H31Br2ClN4O2
Molecular Weight
638.82
References & Citations
[1]Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58 (21) :4947-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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