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(Rac) -SNC80

CAT: 0804-HY-101202A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101202A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Rac) -SNC80 is a racemate of SNC80. SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment[1][2][3][4][5][6].
CAS Number
1217643-87-2
Product Name Alternative
(Rac) -NIH 10815
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-snc80.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CC)CC)C1=CC=C(C(N2C(C)CN(CC=C)C(C)C2)C3=CC=CC(OC)=C3)C=C1
Molecular Formula
C28H39N3O2
Molecular Weight
449.63
References & Citations
[1]Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr;148:77-86.|[2]Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273 (1) :359-66.|[3]Calderon SN, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+) -4-[ (alpha R) -alpha- ((2S,5R) -4-allyl-2,5-dimethyl-1-piperazinyl) -3- methoxybenzyl]-N, N-diethylbenzamide (SNC 80) : a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37 (14) :2125-8.|[4]Metcalf MD, et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3 (7) :505-9.|[5]Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159.|[6]Dripps IJ, et al. Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175 (6) :891-901.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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