HDAC8-IN-1

HDAC8-IN-1

• CAS Number: 1417997-93-3
• UNSPSC Description: HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
• Target Antigen: HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/HDAC8-IN-1.html
• Purity: 99.82
• Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(NO)/C=C/C1=CC=C(OC)C=C1C2=CC=C(C3=CC=CC=C3)C=C2
• Molecular Weight: 345.39
• References & Citations: [1]Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.|[2]Cui J, et al., IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. Cell Death Dis. 2021 May 18;12(6):501.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported