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Sirt2-IN-7

CAT: 0804-HY-151185Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151185Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sirt2-IN-7 (compound 22) is a selective inhibitor of SIRT2. Sirt2-IN-7 inhibits SIRT2 with an IC50 value and a Ki value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer[1].
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt2-in-7.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCC[C@H](SC1=CC=C(C(Cl)=C1)Cl)CC(N[Ac-KKT-NH2])=O
Molecular Formula
C40H68Cl2N6O6S
Molecular Weight
831.98
References & Citations
[1]Kalbas D, et al. Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives. Biochemistry. 2022 Aug 16. doi: 10.1021/acs.biochem.2c00211. Epub ahead of print. PMID: 35972884.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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