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Sirt2-IN-6

CAT: 0804-HY-145958Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145958Size:1 Each
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Description
Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer[1].
CAS Number
2243151-81-5
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt2-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C)N=C1)NC2=CC=C(C=C2)OCC3=CC(NC(CSC4=NC(C)=CC(C)=N4)=O)=CC=C3
Molecular Formula
C26H26N6O3S
Molecular Weight
502.59
References & Citations
[1]Yang LL, et, al. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT2

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